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Laboratory counter top with beakers containing methylene blue liquid.

The Science Behind Brain Fog Support

Exciting Research Supporting Be-OnGuard Brain Fog Support 

Neurotransmitters: Methylene Blue inhibits monoamine oxidase and acetylcholinesterase activity, increasing catecholamines and acetylcholine levels. It boosts serotonin and norepinephrine, affecting anxiety, depression, and memory.

Mitochondrial Energy: Methylene Blue assists brain cell respiration by increasing oxygen and donating electrons to the electron transport chain within mitochondria. This same process creates ATP within mitochondria from the food you eat. So MB contributes to this energy-production process in place of the nutrients you get from your food. Increasing cellular energy positively affects mood and memory.

Neuroprotectant: Methylene Blue is a potent antioxidant. Reactive oxygen species are produced inside mitochondria. The first free radical that is formed inside a cell is superoxide. MB will bind to superoxide and reduce it to water. It stops the oxidative cascade at its very beginning before it gets a chance to do damage.

Combining Methylene Blue with our Mineral Oxide and Vitamin C makes an unbeatable combination. This specific powerhouse combination is only available through this product.


A Clinically Studied Ingredient Shown to Support Memory and Brain Health

Methylene Blue dropped into water

Methylene Blue


Methylene Blue boosts brain health and function in several ways. But two, in particular, stand out.

  1. Methylene Blue improves memory. Unlike other nootropics, which often work by increasing neurotransmitter synthesis and neural signaling, Methylene Blue enhances memory by increasing brain cell respiration. Or how the brain cell utilizes oxygen.

  2. Methylene Blue is an antioxidant. Methylene Blue has a unique mechanism of action that is fundamentally different from traditional antioxidants. During cellular respiration, the first free radical formed inside a cell is superoxide (O2). Methylene Blue binds to superoxide and reduces it to water. It stops the oxidative cascade at its very beginning. Before it gets a chance to do damage.


Methylene blue improves brain oxidative metabolism and memory retention in rats

Callaway NL, Riha PD, Bruchey AK, Munshi Z, Gonzalez-Lima F.

The brain metabolic enhancer methylene blue improves discrimination learning in rats.

Wrubel KM, Riha PD, Maldonado MA, McCollum D, Gonzalez-Lima F.

Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats.

Callaway NL, Riha PD, Wrubel KM, McCollum D, Gonzalez-Lima F.

Neurosci Lett. 2002 Oct 31;332(2):83-6. doi: 10.1016/s0304-3940(02)00827-3.

Memory facilitation by methylene blue: dose-dependent effect on behavior and brain oxygen consumption.

Riha PD, Bruchey AK, Echevarria DJ, Gonzalez-Lima F.

Eur J Pharmacol. 2005 Mar 28;511(2-3):151-8. doi: 10.1016/j.ejphar.2005.02.001.

Extinction memory improvement by the metabolic enhancer methylene blue.

Gonzalez-Lima F, Bruchey AK.

Learn Mem. 2004 Sep-Oct;11(5):633-40. doi: 10.1101/lm.82404.

Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways.

Atamna H, Nguyen A, Schultz C, Boyle K, Newberry J, Kato H, Ames BN.

FASEB J. 2008 Mar;22(3):703-12. doi: 10.1096/fj.07-9610com. Epub 2007 Oct 10.

Neuroprotective and Functional Improvement Effects of Methylene Blue in Global Cerebral Ischemia.

Lu Q, Tucker D, Dong Y, Zhao N, Zhang Q.

Mol Neurobiol. 2016 Oct;53(8):5344-55. doi: 10.1007/s12035-015-9455-0. Epub 2015 Oct 3.

Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model.

Paban V, Manrique C, Filali M, Maunoir-Regimbal S, Fauvelle F, Alescio-Lautier B.

Neuropharmacology. 2014 Jan;76 Pt A:68-79. doi: 10.1016/j.neuropharm.2013.06.033. Epub 2013

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